Did you know that dogs can suffer from a condition called paroxysmal dyskinesia (PxD)?

PxDs (also known as movement disorders) are a heterogeneous group of disorders in humans and animals characterized by recurrent episodes of sudden, abnormal, involuntary movements and dystonia of variable duration. PxDs can be inherited or acquired and can be primary or secondary to various underlying disorders. Patients with primary PxDs have normal neurologic examination between episodes and this condition is increasingly recognised in dogs.

Although it was first reported in 1984 the condition has remained poorly characterized in the Norwich Terrier. However, the Neurological team at the AHT, under the lead of Head of Department Luisa De Risio, conducted a ground breaking study to not only characterise the phenomenology, clinical course, and family history of paroxysmal dyskinesia in the Norwich Terrier but also to estimate its prevalence in the United Kingdom.

The questionnaire based study found that 13% of the dogs studied were classified as affected by paroxysmal dyskinesia. The results of this work have been published in the peer reviewed journal ‘Movement Disorders Clinical Practice’

Further research is ongoing to clarify the pathophysiology and identify the genetic basis of this condition.

Click here to read more about this research

Can you help our PxD research?

We are collecting cheek swab DNA samples from Norwich Terriers with suspected PxD and Norwich Terriers over the age of six years with no history of neurological disease.

If you have a dog that fits these criteria and you are happy to contribute to the study please email Chris Jenkins on chris.jenkins@aht.org.uk